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Cephalexin is contra-indicated in patients with known allergy to the cephalosporin group of antibiotics. Medications with known interactions with Keflex include blood thinners, probenecid, and Metformin. Cephalexin is contra-indicated in patients with known allergy to the cephalosporin group of antibiotics. Cephalexin is an antibiotics used to suppress the growth of micro-organisms such as bacteria, fungi, or protozoa. Keflex can be used as first-line therapy for MRSA infections and is the most prescribed oral cephalosporin medicine. Cephalexin is a broad-spectrum antibiotic used to treat infections caused by bacteria such as pneumonia and bone, ear, skin, and urinary tract infections.